This study looks at the effect of manipulating the water concentration of certain e-liquids on sensory perception.
This study looks at the effect of manipulating water concentration on e-cigarettes that contain aldehyde flavor chemicals on sensory perception. Regular e-cigarette users will be asked to complete 2 lab sessions in which they will sample 4 nicotine containing e-liquids. Each e-liquid will be sampled in four water concentration manipulations. Researchers will examine influence of flavor and water concentrations on sensory experience including appeal/liking and irritation and harshness.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
31
E-liquid containing 36mg/ml pronated nicotine will be administered with no alteration to water concentration.
E-liquid containing 36mg/ml pronated nicotine will be administered with 5% total water concentration of e-liquid.
E-liquid containing 36mg/ml pronated nicotine will be administered with 10% total water concentration of e-liquid.
Yale School of Medicine
New Haven, Connecticut, United States
Irritation/Harshness
Change in irritation at each water level as measured by the computerized Generalized Labeled Magnitude Scale (gLMS). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. The Generalized Labeled Magnitude Scales (gLMS) are category ratio scales with seven semantic labels: "no sensation", "barely detectable", "weak", "moderate", "strong", "very strong", and "strongest imaginable", positioned quasi-logarithmically as per empirically determined semantic magnitudes on a 0-100 scale (strongest imaginable at the 100 end).
Time frame: immediately after intervention, up to 15 minutes
Appeal Assessed Using the Labeled Hedonic Scale (LHS) Ranging From -100 to 100
Change in appeal at each water level as measured by the computerized Labeled Hedonic Scale (LHS). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. The Labeled Hedonic Scale (LHS) is a bipolar category ratio scale that ranges from -100 (most disliked, minimum score) to 100 (most liked, maximum score), with 'neither liked nor disliked' as midpoint (0). Scores range from -100 (minimum) to 100 (maximum). Negative scores indicate dislike (lack of appeal) and positive scores indicate liking (appeal).
Time frame: immediately after intervention, up to 15 minutes
Appeal Assessed Using the Drug Effects Questionnaire (DEQ)
Change in appeal at each water level as measured by the computerized version of the Drug Effects Questionnaire (DEQ). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. A modified version of the Drug Effects Questionnaire (DEQ) will be used in which participants rate acute responses to the e-cigarette on a 0-100mm scale from "not at all" (0mm) to "extremely" (100mm).
Time frame: immediately after intervention, up to 15 minutes
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E-liquid containing 36mg/ml pronated nicotine will be administered with 20% total water concentration of e-liquid.