The Effects of Jing Si Herbal Tea Liquid Packets on Fatigue in Patients With Inflammatory Arthritis

Buddhist Tzu Chi General Hospital150 enrolled

Overview

Fatigue is a common feature in patients with rheumatic conditions. Fatigue can lead to a decline in physical function, self-confidence, cognitive status, and work performance and significantly impact the quality of life. While pain and inflammation of arthritis can be well controlled nowadays attributed to the advances in anti-rheumatic medications, fatigue remains a challenge. Even with proper therapies for arthritis, the prevalence of severe fatigue is more than 30%, which is a significant burden to both physicians and patients. However, there is no regimen to alleviate fatigue among patients with inflammatory arthritis. Finding a way to combat fatigue will significantly help improve patients' physical and mental state and family society. To investigate the efficacy of Jing Si Herbal Tea Liquid Packets on fatigue in patients with inflammatory arthritis, the investigators propose a two-year research project to recruit approximately 150 patients with fatigue and inflammatory arthritis, including rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. This project is designed as a randomized, double-blind, placebo-controlled study. The recruited patients will be randomized to receive Jing Si Herbal Tea Liquid Packets or a matching placebo in combination with the background regular anti-rheumatic therapy. The severity of fatigue will be obtained by questionnaire. Clinical parameters, including demographic data and disease activities, will be collected during each visit.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

150

Conditions

Arthritis Rheumatoid Arthritis Ankylosing Spondylitis Psoriatic Arthritis Fatigue

Interventions

Jing Si Herbal Tea LIQUID PACKETSDIETARY_SUPPLEMENT

intake Jing Si Herbal Tea LIQUID PACKETS twice daily for three months

PlaceboDIETARY_SUPPLEMENT

intake Placebo twice daily for three months

Eligibility

Sex: ALLMin age: 20 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * inflammatory arthritis, any of the following diagnosis 1. Rheumatoid arthritis, based on ACR (American College of Rheumatology) classification criteria 2. Ankylosing spondylitis, based on modified New York Criteria 3. Psoriatic arthritis, based on 2006 CASPAR (ClASsification criteria for Psoriatic ARthritis) criteria Exclusion Criteria: 1. active infection or chronic infection 2. uncontrolled disease status of inflammatory arthritis 3. unwilling to take herbal tea 4. with difficulty for return visits

Locations (1)

Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Hualien City, Taiwan

Outcomes

Primary Outcomes

Change in level of fatigue [Time Frame: 4, 8, 12 weeks after Jing Si Herbal Tea Liquid Packets]

Fatigue assessment measured by the functional assessment of chronic illness Therapy- Fatigue (FACIT- F) (0-52; higher score=less fatigue)

Time frame: Change of fatigue level every 4 weeks until 12 weeks after Jing Si Herbal Tea Liquid Packets

Secondary Outcomes

Change in disease activity of inflammatory arthritis [Time Frame: 4, 8, 12 weeks after Jing Si Herbal Tea Liquid Packets]

Disease activity of inflammatory arthritis measured by the Disease Activity Score based on 28 joints (DAS28) (0-9.55; higher score=more active) for rheumatoid arthritis, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (0-10; higher score=more active) for ankylosing spondylitis, and Disease Activity in PSoriatic Arthritis (DAPSA) (0-204; higher score=more active) for psoriatic arthritis.

Time frame: Change of disease activity every 4 weeks until 12 weeks after Jing Si Herbal Tea Liquid Packets

Data from ClinicalTrials.gov

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