Assessment of Autogenous Dentin Graft in Treatment of Infra-bony Defect

October 6 University20 enrolled

Overview

The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.

In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Periodontitis (Stage 3)

Interventions

Autogenous demineralized dentin nanoparticlesPROCEDURE

Effect of Autogenous demineralized dentin nanoparticles in bone gain in infrabony defect

Eligibility

Sex: ALLMin age: 16 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with good systemic health and no contraindication for periodontal surgery. * Patients who are able to maintain good oral hygiene. * Gingival thickness for the site selected should be ≥1mm. * Probing depth of ≥ 6mm. * Patient has at least one hopeless teeth Exclusion Criteria: * Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc….). * Medically compromised patients. * Smokers and alcoholic abusers * People who suffer from any systemic disease that affect the periodontium. * Pregnant, postmenopausal women. * People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month. * People who use mouth washes regularly * Participants in other clinical trials.

Locations (1)

October 6 University

Cairo, Egypt

Outcomes

Primary Outcomes

Vertical bone loss

vertical bone loss was measured from cementoenamel junction (CEJ) to the base of the bone defect in each site in group I \& II.

Time frame: 6 months

Clinical attachment level

Clinical attachment level was measured at baseline and 6 months

Time frame: 6 months

Probing pocket depth

Probing pocket depth was measured at baseline and 6 months

Time frame: 6 months

Bone gain

The bone gain is calculated by: * Preoperative VBL (at baseline): measured as the distance from cementoenamel junction (CEJ) to the base of the bone defect. * Postoperative VBL (after 6 months) measured as the distance from cementoenamel junction (CEJ) to the base of the bone formation. * Postoperative bone fill (bone gain after 6 months) \[measured by subtracting the preoperative VBL from the postoperative VBL\].

Time frame: 6 months

Secondary Outcomes

Plaque Index

plaque index was measured at baseline, 3, 6 months

Time frame: 6 months

Gingival index

Gingival index was measured at baseline, 3, 6 months

Time frame: 6 months

Data from ClinicalTrials.gov

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