Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment

Technical University of Munich40 enrolled

Overview

This study aims at investigating the feasibility of recruitment and application of a method regarding early detection of subclinical changes in cardiac health after completion of acute cancer treatment during childhood and adolescence.

Cardiovascular late effects following treatment for pediatric cancer are problematic. Early detection of subclinical changes is hardly possible using conventional diagnostic methods, but seems to be feasible during physical strain (exercise stress echocardiography). This feasibility study examines as main objective the recruitment strategy and investigation method in 10-25-year olds in the first and fifth year after the end of acute anti-cancer therapy (n=40 participants with a history of childhood cancer and n=40 control subjects). The heart function is examined by means of exercise stress echocardiography and spiroergometry in comparison with healthy age- and gender-matched control subjects. Secondary aims are the evaluation of aditional echocardiography markers and levels of physical activity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiovascular Diseases Pediatric Cancer

Interventions

Exercise stress echocardiographyDIAGNOSTIC_TEST

Study participants perform an exercise stress echocardiography on a semi-supine bicycle ergometer using using a continuous incremental bicycle protocol with a work rate increment every 3 minutes according to gender and weight.

Eligibility

Sex: ALLMin age: 10 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria for all participants: * Aged between 10 and 25 years * Body height of ≥1,40m (required for performing the examination on the semi supine bicycle ergometer) * Signed informed assent (minor participant) and consent (legal guardian and full-aged participant) Additional inclusion criteria for participants following cancer treatment: * Completion of acute cancer treatment with anthracyclines and/or chest radiation * End of treatment 12 months and five years ago (± three months) * Medical approval for study participation Additional inclusion criteria for healthy control subjects: \- Appropriate as matched pair with respect to age and gender Exclusion Criteria: * Known cardiovascular diseases (incoherent with cardiotoxic treatment) * Inability to follow study instructions (e.g., mental retardation, language) * Acute orthopedic injury (e.g., bone fracture) or orthopedic impairments that preclude examination on a bicycle ergometer (e.g., instable prosthetic device) All participants receive a basic physical and cardiological examination at rest as part of the study protocol to ensure capability before performing the exercise stress echocardiography.

Locations (1)

Institute of Preventive Pediatrics, Department of Sport and Health Sciences, Technical University of Munich, Germany

Munich, Germany

Outcomes

Primary Outcomes

Feasibility Criteria 1 - Recruitment Rate

The number of children, adolescents and young adults with a history of pediatric cancer who agree to participate compared to the total number approached for this study.