This study will validate a coordinate-based 3-dimensional echocardiographic technique for the assessment of cardiac size and function in children and young adults with functional single ventricles.
The accuracy of current echocardiographic techniques for measuring ventricular size and function are limited by geometric assumptions, which are particularly problematic in malformed hearts or functional single ventricles, as well as the inability to visualize the entire heart at one time from a single imaging window, and higher heart rates degrading 3D imaging volume rates. This study will validate a coordinate-based 3-dimensional echocardiographic technique for the assessment of cardiac size and function in children and young adults with functional single ventricles, including a comparison to the gold standard of cardiac MRI.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
100
Non-invasive imaging of the heart to evaluate structure and function.
Non-invasive ultrasound of the heart to evaluate structure and function through 3D imaging.
Duke University
Durham, North Carolina, United States
RECRUITINGCardiac function of the right ventricle as measured by ejection fraction
Ejection Fraction (EF) is a measurement of the percentage of blood leaving your heart each time it squeezes (contracts)with each heart beat.
Time frame: Day 1
Cardiac function of the left ventricle as measured by ejection fraction
Ejection Fraction (EF) is a measurement of the percentage of blood leaving your heart each time it squeezes (contracts)with each heart beat.
Time frame: Day 1
Right ventricular dimension as measured by end diastolic volume
End Diastolic Volume (EDV) is the volume of blood in a ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole.
Time frame: Day 1
Right ventricular dimension as measured by end systolic volume
End Systolic Volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole.
Time frame: Day 1
Left Ventricular Dimension as measured by end diastolic volume
End Diastolic Volume (EDV) is the volume of blood in a ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole.
Time frame: Day 1
Left Ventricular Dimension as measured by end systolic volume
End Systolic Volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole.
Time frame: Day 1
Left Ventricular Dimension as measured by end diastolic diameter
End Diastolic Diameter (EDD) is the diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Day 1
Left Ventricular Dimension as measured by end systolic diameter
End Systolic Diameter (ESD) is the diameter across the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter.
Time frame: Day 1
Right Ventricular Function as measured by tricuspid annular plane systolic excursion
Tricuspid Annular Plane Systolic Excursion (TAPSE) is a measurement of the decent of the right ventricular base towards a relatively fixed apex.
Time frame: Day 1
Right Ventricular Function as measured by myocardial performance index
RV Myocardial Performance Index (MPI) is a measurement that incorporates tricuspid valve closure to opening time and right ventricular ejection time to evaluate efficiency of the ventricle.
Time frame: Day 1
Left Ventricular Function as measured by myocardial performance index
LV Myocardial Performance Index (MPI) is a measurement that incorporates mitral valve closure to opening time and left ventricular ejection time to evaluate efficiency of the ventricle.
Time frame: Day 1
Left Ventricular Function as measured by tissue doppler imaging
Tissue Doppler Imaging (TDI) a measurement of the velocity of myocardial motion.
Time frame: Day 1
Left ventricular function as measured by shortening fraction
Shortening fraction(SF) is a measurement of the percentage of change in left ventricular diameter during systole.
Time frame: Day 1
Presence of ventricular dysfunction as measured by strain
Strain is a measure of deformity in the muscle of the ventricle.
Time frame: Day 1