HL-085+Vemurafenib to Treat Advanced Melanoma Patients With BRAF V600E/K Mutation

Inclusion Criteria: * Male or female patients ≥ 18 years of age; * Patients with histological confirmed advanced melanoma; * BRAF V600E/ V600K mutation positive； * At least 1 site of radiographically measurable disease by RECIST 1.1 * Eastern Cooperative Oncology Group (ECOG) Performance Status(PS) of 0 to 1; * Life expectancy ≥ 3 months; * Can swallow the medicine, * UCG documenting LVEF ≥50% within seven days prior to initiation of dosing; * Adequate hematologic, renal, and liver function as defined by laboratory values performed within 42 days prior to initiation of dosing: Absolute neutrophil count (ANC) ≥ 1.5 x 109/L; Platelet count ≥ 1.0 x lower limit of normal (LLN); Hemoglobin ≥ 90 g/L; Serum creatinine ≤ 1.5 x upper limit of normal (ULN); Serum aspartate transaminase (AST) or serum alanine transaminase (ALT)≤ 2.5x ULN, and ≤ 5.0 x ULN if liver metastases are present. Serum alkaline phosphatase （ALP）≤ 2.5x ULN and ≥ 2.5 x ULN if bone metastases are present; Total serum bilirubin ≤ 1.5 x ULN; Serum albumin ≥ 30 g/L; Coagulation function：INR ≤1.5×ULN；Activated partial thrombin time (APTT) ≤1.5×ULN; Creatine kinase (CK) ≤1× ULN * 10\. Before study entry, written informed consent must be obtained from the patient prior to performing any study-related procedures. * 11\. Be willing and able to complete all the study procedures and follow-up examinations. Exclusion Criteria: * Patients who have been previously treated with a BRAF and/or MEK inhibitors. * Patients with active CNS lesions are excluded (i.e. those with radiographically unstable, symptomatic lesions). However, patients treated with stereotactic therapy or surgeries are eligible if patient remains without evidence of disease progression in brain ≥ 3 months. * Patients accepted other administration of anti-cancer study therapies within 4 weeks prior to initiation of dosing; * Dysphagia，refractory nausea, vomiting, small bowel resection or any other gastrointestinal ailment that would preclude study drug absorption. * Major surgery or traumatic injury (exclude baseline biopsy ) within 14 days prior to first dose of study treatment * Patients have mean QTcB interval ≥ 480 msec, or any history of congenital long QT syndrome or with ongoing concomitant treatment with medications that prolong the QT interval at screening; * Serious illnesses, such as: cardiovascular disease (uncontrolled congestive heart failure, uncontrolled hypertension, cardiac ischemia, myocardial infarction, and severe cardiac arrhythmia), bleeding disorders, symptomatic autoimmune diseases, severe obstructive or restrictive pulmonary diseases, uncontrolled endocrine disorders (hypothyroidism, hyperthyroidism and diabetes mellitus), retinopathy, active systemic infections, and inflammatory bowel disorders. This includes known HIV or AIDS-related illness, or active HBV and HCV. * Active infection or antibiotics within one-week prior to study, including unexplained fever * Lactating females or pregnant females. * Systemic steroid or other immunosuppressive therapy within 4 weeks of starting the study. * Any significant psychiatric disease, medical intervention, or other condition, which in the opinion of the principal investigator, could prevent adequate informed consent or compromise participation in the clinical trial.