FAPI-CUP- Evaluating FAPI as a Novel Radiopharmaceutical for Cancer of Unknown Primary

Inclusion Criteria: 1. Participant has provided written informed consent 2. Participants aged 18 years or over at screening 3. Diagnosed with CUP based on a diagnostic work-up, including, but not limited to; a detailed clinical assessment; a CT scan of the chest/abdomen, and pelvis; pathological review of tumour tissue; and other appropriate tests as per the Cancer Council Optimal Care Pathway guidelines 4. Has not commenced current line of systemic treatment 5. Eastern Cooperative Oncology Group performance status 0 - 2 6. Life expectancy greater than 3 months 7. Adequate hematologic and organ function to commence systemic treatment, defined by the following laboratory results: 1. Haemoglobin ≥ 90g/L 2. Absolute neutrophil count ≥1.5 x 109/L 3. Platelet count ≥ 100 x 109/L 4. Creatinine clearance ≥ 30mL/min 5. Serum bilirubin ≤ 1.5 x upper limit of normal (ULN); patients with known Gilbert's disease may have a bilirubin ≥ 3.0 x ULN 6. Aspartate transaminase (AST) or alanine transaminase (ALT) ≤2 x ULN (or ≤ 5 x ULN in the presence of liver metastases) 8. Willing and able to comply with all study requirements, including all treatment and required assessments including follow-up procedures, in the investigator's judgment Exclusion Criteria: 1. Uncontrolled medical or psychological conditions that may prevent commencement of systemic treatment. 2. Major surgical procedure within 6 weeks prior to study registration or active infection requiring systemic treatment a. Placement of vascular access devices is not considered major surgery. 3. Concurrent illness, including severe infection that may jeopardise the ability of the participant to undergo procedures outlined in this protocol with reasonable safety 4. Prior cancer diagnosis with the exception of: 1. Malignancy treated with curative intent and with no known active disease ≥ 3years and of low potential risk of recurrence 2. Adequately treated basal cell or squamous cell skin carcinoma or non-invasive melanoma 3. Adequately treated non-muscle invasive bladder cancer (Tis, Ta and low grade T1 tumours) 4. Adequately treated carcinoma in situ without evidence of disease 5. Cancer subjects with incidental histologic findings of prostate cancer that, in the opinion of the Investigator, is not deemed to require active therapy (e.g., incidental prostate cancer identified following cystoprostatectomy that is tumour/node/metastasis stage ≤ pT2N0) 5. Greater than one prior line of systemic treatment 6. Known allergy or reaction to 18F or 68Ga tracer