Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting ∼1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints. Fexofenadine has been widely used to treat various allergic diseases, like allergic rhinitis, conjunctivitis and chronic idiopathic urticaria. the molecular mechanisms underlying fexofenadine mediated inhibition of TNF-α signalling
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
80
tablet
tablet
Beni-Suef Hospital
Banī Suwayf, Egypt
RECRUITINGFaculty of Medicine - Beni Suef Hospital
Banī Suwayf, Egypt
RECRUITINGACR 20%
improvement criteria (ACR20) response rate based on the count of tender/swollen joints,
Time frame: at baseline
ACR 20%
improvement criteria (ACR20) response rate based on the count of tender/swollen joints,
Time frame: at week 12
(HAQDI)
HAQ-DI (Health Assessment Score- Disability index), in which patients are asked to rate their capacity to perform 20 activities of daily living (ADL). Scoring within each section is from 0 (without any difficulty) to 3 (unable to do). For each section the score given to that section is the worst score within the section
Time frame: at baseline
(HAQDI)
HAQ-DI (Health Assessment Score- Disability index), in which patients are asked to rate their capacity to perform 20 activities of daily living (ADL). Scoring within each section is from 0 (without any difficulty) to 3 (unable to do). For each section the score given to that section is the worst score within the section
Time frame: at week 12
CRP
the level of CRP
Time frame: at baseline
CRP
the level of CRP
Time frame: at week 12
TNF-α
Serum level Tumor necrosis factor- alpha (TNF-α)
Time frame: at baseline and at week 12
IL6
Serum level of IL6
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Time frame: at baseline and at week 12