NCT05264246 - Evaluation of an Anti-Shivering Protocol Cardiac Arrest | Crick | Crick

Evaluation of an Anti-Shivering Protocol Cardiac Arrest

N/ATerminatedNCT05264246

Methodist Health System165 enrolled

Overview

This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019.

This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019. To allow for an adequate washout period, patients who were initiated on TTM before April 22, 2019 will be in the "before" group and patients initiated on TTM on or after June 1, 2019 will be in the "after" group. Patients will be identified based on electronic medical records search of order sets utilized in TTM and confirmed with manual chart review. Statistical analysis will be performed as detailed below.

Study Type

OBSERVATIONAL

Enrollment

165

Conditions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * Diagnosis of cardiac arrest * Initiation of TTM via Arctic Sun® device Exclusion Criteria: * Initiation of TTM \> 12 hours after cardiac arrest * Receiving NMBs for an indication other than TTM * Early termination of TTM (less than 24 hours)

Locations (1)

Methodist Dallas Medical Center

Dallas, Texas, United States

Outcomes

Primary Outcomes

NMB usage

vecuronium or cisatracurium

Time frame: June 1, 2017 - May 31, 2021

Secondary Outcomes

NMB usage

Proportion of patients that required any vecuronium boluses Number of vecuronium boluses administered Proportion of patients that required initiation of cisatracurium infusion

Time frame: June 1, 2017 - May 31, 2021

Patients discharged home

Proportion of patients discharged home

Time frame: June 1, 2017 - May 31, 2021

Patients with a breakthrough fever (temperature > 38°C) in the first 72 hours of TTM initiation

Proportion of patients with a breakthrough fever (temperature \> 38°C) in the first 72 hours of TTM initiation

Time frame: First 72 hours of TTM initiation

Proportion of patients cooled to 33°C versus 36°C

number of patients at desired temperature range

Time frame: June 1, 2017 - May 31, 2021

Time to target temperature from initiation of TTM

time in minutes

Time frame: June 1, 2017 - May 31, 2021

ICU length of stay

number of days

Time frame: June 1, 2017 - May 31, 2021

Data from ClinicalTrials.gov

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