Maximal Exercise Capacity at 2500 m of High Altitude

University of Zurich28 enrolled

Overview

The impact of hypoxia on maximal work rate during incremental ramp exercise within 3-6 hours after arriving at 2500m of high altitude in patients with precapillary pulmonary hypertension

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

High Altitude Pulmonary Hypertension Maximal Exercise Capacity

Interventions

Maximal Exercise CapacityPROCEDURE

Maximal Exercise Capacity in incremental ramp exercise tests.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Informed consent as documented by signature (Appendix Informed Consent Form) * PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure \>20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic right-heart catheterization Exclusion Criteria: * resting partial pressure of oxygen \<8 kilopascal at Zurich at 490 m low altitude * exposure to an altitude \>1000 m for ≥3 nights during the last 2 weeks before the study * inability to follow the procedures of the study * other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)

Locations (1)

Respiratory Clinic, University Hospital of Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Maximal work rate

Change in maximal work rate in Watt at 2500 vs. 490 m

Time frame: 30 hours

Secondary Outcomes

Heart rate

Change in cardiorespiratory measurements: heart rate during a cycle incremental ramp exercise test at high altitude vs. low altitude

Time frame: 30 hours

Ventilation

Change in cardiorespiratory measurements: ventilation during a cycle incremental ramp exercise test at high altitude vs. low altitude

Time frame: 30 hours

Oxygen uptake

Change in cardiorespiratory measurements: Oxygen uptake, SpO2, blood gases during a cycle incremental ramp exercise test at high altitude vs. low altitude

Time frame: 30 hours

Arterial blood oxygenation saturation

Change in cardiorespiratory measurements: Oxygenation (SpO2) during a cycle incremental ramp exercise test at high altitude vs. low altitude

Time frame: 30 hours

Blood gases

Change in blood gases during a cycle incremental ramp exercise test at high altitude vs. low altitude

Time frame: 30 hours

Hemodynamics

Change in hemodynamics assessed by echocardiography

Time frame: 30 hours

Borg dyspnoea and leg fatigue scale

Change in post-exercise Borg dyspnoea and leg fatigue scale during a cycle incremental ramp exercise test at high altitude vs. low altitude

Data from ClinicalTrials.gov

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