Cluster Headache Treatment With Rimegepant

Inclusion Criteria: * Having a diagnosis of recurrent cluster headaches, as described by ICHD-3 (International Classification of Headache Disorders-3): * Severe or very severe unilateral orbital, supraorbital and/or temporal pain lasting 15-180 minutes, when untreated. * Headache is accompanied by at least one of the following: * Ipsilateral conjunctival injection and/or lacrimation; * Ipsilateral nasal congestion and/or rhinorrhea; * Ipsilateral eyelid edema; * Ipsilateral forehead and facial sweating; * Ipsilateral miosis and/or ptosis; * A sense of restlessness or agitation. * Headache attacks occur at a frequency between every other day and 8 per day. * Headaches are not attributed to another disorder. * Subjects able to distinguish cluster headache attacks from other headache disorders, such as migraine. * Subjects on prophylactic headache medicines other than verapamil will be permitted to remain on these with possible headache-prophylactic effects if the dose is stable for at least 2 months (onabotulinumtoxinA injections stable for 6 months) prior to the screening visit and the dose is not expected to change during the course of the study. * Prior MR (magnetic resonance) imaging of head (CT if MRI contraindicated) performed after the onset of headaches. * Subjects agree to refrain from starting a new prophylactic cluster headache medicine, including steroids and nerve blocks, during the course of the study. * Subjects are required to have a cluster headache attack fre-quency ranging from one attack every other day to eight attacks per day, with at least four total attacks during the one-week prospective baseline period. Additionally, episodic cluster headache patients are required to have a history of cluster head-ache period lasting at least 6 weeks. Exclusion Criteria: * Subjects with a history of an adverse reaction to CGRP (calcitonin gene-related peptide) antibodies or another CGRP antagonist (gepant). * Subjects with episodic cluster who are felt to be toward the end of their cluster cycle (estimated to be within the last 4 weeks). * Pregnancy (negative serum pregnancy testing at enrollment and use of contraception considered to be effective). * Subjects with a history of uncontrolled, unstable, or recently diagnosed cardiovascular disease, such as ischemic heart disease, coronary artery vasospasm, and cerebral ischemia. Subjects with myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG), stroke, or transient ischemic attack (TIA) in the 6 months prior to screening. * Subjects with other pain syndromes, psychiatric conditions, dementia or significant neurological disorders that, in the investigator's opinion might interfere with study assessments. * Use of peripheral nerve blocks (e.g., occipital, supraorbital, auriculotemporal, and/or sphenopalatine ganglion nerve blocks) one month prior to enrollment. * Use of opioids or barbiturates more than 5 days per month. * Use of other small molecule CGRP antagonist (gepant) 1 month prior to enrollment or during duration of study * Use of verapamil during the study * Use of CGRP monoclonal antibodies 3 months prior to enrollment or during duration of study. * Subjects with a secondary cluster headache related to an underlying structural etiology identified by imaging (CT or MRI).