To compare the anti-nausea and vomiting effect between glycopyrronium and ondansetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium to prevent postoperative nausea and vomiting.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
480
Glycopyrronium (0.2mg) was intravenously given at the ending of the surgery.
Glycopyrronium (4mg) was intravenously given at the ending of the surgery.
The Second Affiliated Hospital, Chongqing Medical University
Chongqing, Chongqing Municipality, China
RECRUITINGincidence of postoperative nausea and vomiting
postoperative nausea and vomiting is recorded according to follow-up visits after surgery
Time frame: from the ending of surgery to 24 hours after surgery
intensity of postoperative nausea
intensity of postoperative nausea is assessed using Numeric Rating Scale (0-10, 0 represents no uncomfortable felling, 10 represents tolerableness)
Time frame: from the ending of surgery to 24 hours after surgery
incidence of postoperative vomiting
postoperative vomiting is recorded according to follow-up visits after surgery
Time frame: from the ending of surgery to 24 hours after surgery
incidence of intervention requirement for nausea and vomiting
this event is recorded according to follow-up visits after surgery
Time frame: from the ending of surgery to 24 hours after surgery
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