Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic)

University Hospital, Basel, Switzerland176 enrolled

Overview

This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.

Implant associated infections in orthopaedics and trauma surgery are a well-known and feared complication. Prosthetic-joint infection (PJI) is caused by a biofilm which is located atop the surface of the implant which as growing with the duration of the PJI. This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.

Study Type

OBSERVATIONAL

Enrollment

176

Conditions

Prosthetic-joint Infection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who underwent a revision surgery of hip, knee and shoulder arthroplasties operated at the university hospital of Basel between 2011 and 2021, * patients who had a PJI as a suspected diagnosis and * have microbiological cultures from sonication fluid from removed prosthesis. Exclusion Criteria: * patients in the database who 1. have non-bacterial microbiological positive cultures (e.g. fungal infection) and 2. have not received a sonication of the removed prosthesis during the diagnostic process

Locations (1)

Department of Orthopaedics and Traumatology, University Hospital Basel

Basel, Switzerland

Outcomes

Primary Outcomes

number of bacteria

number of bacteria detected during revision surgery will be taken from the sonication fluid and the quantitative analysis of the microbiological samples

Time frame: one time assessment at baseline

duration of the infection

Time frame: one time assessment at baseline

Data from ClinicalTrials.gov

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