This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.
The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.
Study Type
OBSERVATIONAL
Enrollment
300
Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
RECRUITINGRecurrence assessed by ECG, Holter reports and outpatient physicians
Recurrence includes atrial fibrillation and atrial flutter. Recurrence features including pattern, duration, burden, etc. will be recorded.
Time frame: at 1-year follow-up after ablation
All-cause mortality assessed by telephone follow-up or medical records
Time and cause of death will be recorded.
Time frame: at 1-year follow-up after ablation
Improvement in life quality assessed by QOLSF36 Questionnaire
Life quality will be assessed at baseline and 1-year FU. Improvement in life quality indicates that patients can benefit from the catheter ablation.
Time frame: at 1-year follow-up after ablation
Improvement in left atrial function assessed by echocardiography
Left atrial function will be assessed at baseline and 1-year FU. Improvement in atrial function indicates that ablation can restore atrial function.
Time frame: at 1-year follow-up after ablation
Embolic events assessed by physicians and further examinations like ultrasound, MRI
Embolism may be related to atrial fibrillation. Embolism will be assessed by physicians according to patients' symptoms and signs at clinic or by telephone. If a patient's clinical presentation indicates embolism, the patient will be further assessed by ultrasound, MRI, etc.
Time frame: at 1-year follow-up after ablation
Hospitalization for heart failure, atrial fibrillation or atrial flutter
Postoperative hospitalization indicate worse prognosis.
Time frame: at 1-year follow-up after ablation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.