A Novel Role of Alpha Lipoic Acid in Comparison With Selenium in Mitochondrial Resuscitation and miRNA-126 Expression in Hemodialysis Patients

Ain Shams University68 enrolled

Overview

An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively. Serum levels of ROS, CoQ10, and miRNA-126 were assessed at base line and after three months for all patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Antioxidative Stress End Stage Renal Disease on Dialysis

Interventions

Alpha lipoic acidDRUG

20 patients who received Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months.

SeleniumDRUG

23 patients who received Selenium 200µg once daily with their routine therapy just a

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * prevalent hemodialysis patients Exclusion Criteria: * Patients with Inflammatory diseases, hepatic or respiratory diseases, smokers and alcoholics, were excluded from the study.

Locations (1)

Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

Change in miRNA-126 level

Fold expression

Time frame: 3 months

Change ROS level (ng/ml)

Using ELISA kit

Time frame: 3 months

Change in Co Q10 level (ng/ml)

Using ELISA kit

Time frame: 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.