Function Magnetic Resonance Imaging to Assess Two Therapeutic Strategies in Multiple Sclerosis (NeuroRehEM).

Change from baseline in Correct Responses

Number of correct responses in both tasks (n-back computerized task and balls Virtual Reality task)

Time frame: Baseline and 10 training days after.

Change from baseline in Reaction Time

This is a primary outcome of the n-back task, which refers to the amount of time (in milliseconds) that elapse from the moment the correct stimulus appears and the correct response is given.

Time frame: Baseline and 10 training days after.

Change from baseline in Omissions

In both tasks will be assessed the number of times that a correct stimulus appear and non-response is given.

Time frame: Baseline and 10 training days after.

Change from baseline in Errors

The number of times that a distractor stimulus appears and a response is given.

Time frame: Baseline and 10 training days after.

Change from baseline in Functional Connectivity in resting state

This is a brain activity measure during resting state through functional magnetic resonance imaging. This outcome will be assessed in both studies. fMRI sequence: T2-weighted echoplanar imaging sequence.

Time frame: Baseline and 10 training days after.

Change from baseline in Functional Connectivity in task performance

This is a brain activity measure during a task performance through functional magnetic resonance imaging. This outcome will be assessed in Virtual Reality study. fMRI sequence: T2-weighted echoplanar imaging sequence.

Time frame: Baseline and 10 training days after.

Change from baseline in SRT-S: Selective Reminding Test (Storing)

A subtest of the BRB-N (The Brief Repeatable Battery of Neuropsychological Tests for MS) which measures memory storage capacity.

Time frame: Baseline and 10 training days after.

Change from baseline in SRT-R: Selective Reminding Test (Retrieval)

This subtest of the BRB-N is a measure of memory retrieval capacity.

Time frame: Baseline and 10 training days after.

Change from baseline in SRT-D: Selective Reminding Test (Delayed)

This BRB-N subtest measures the delayed memory.

Time frame: Baseline and 10 training days after.

Change from baseline in SPART: Spatial Recall Test

A subtest of the BRB-N that measures spatial memory.

Time frame: Baseline and 10 training days after.

Change from baseline in SPART-D: Spatial Recall Test (Delayed)

This BRB-N subtest measures the spatial delayed memory.

Time frame: Baseline and 10 training days after.

Change from baseline in SDMT: Symbol Digit Modalities Test

A BRB-N subtest which measures information processing speed.

Time frame: Baseline and 10 training days after.

Change from baseline in PASAT: Paced Auditory Serial Addition Task

A BRB-N subtest which measures working memory.

Time frame: Baseline and 10 training days after.

Change from baseline in Phonemic Fluency

A language measure that assesses phonemic fluency.

Time frame: Baseline and 10 training days after.

Change from baseline in Semantic Fluency

A language measure that assesses semantic fluency.

Time frame: Baseline and 10 training days after.

Change from baseline in Digit Span Forward

A subtest of the Wechsler Adult Intelligence Scale (WAIS-III) that is an attention measure.

Time frame: Baseline and 10 training days after.

Change from baseline in Digit Span Backward

A WAIS-III subtest that is a working memory measure.

Time frame: Baseline and 10 training days after.

Change from baseline in Letters and Numbers

A WAIS-III subtest that measures working memory.

Time frame: Baseline and 10 training days after.