Plaque Stability and Metabolomics in Coronary Heart Disease

Inclusion Criteria: * Patients who diagnosed with stable coronary heart disease and evaluated for plaque stability by IVUS will be recruited. Exclusion Criteria: * renal insufficiency with serum creatinine \> 20 mg/L; * regnant/lactating women, or the women receive hormone replacement therapy in premenopausal or postmenopausal; * patients have a history of abusing alcohol or other drugs in the past two years, active hepatitis, cirrhosis; * endocrine abnormalities without therapy (diabetic ketoacidosis, thyroid disease, etc.); * The body's inflammatory disease, rheumatoid arthritis, osteoarthritis, ulcerative bowel disease, systemic lupus erythematosus (sle), etc.), myositis/myopathy, cancer; * Dilated cardiomyopathy, valvular heart disease, persistent atrial fibrillation; * patients recently injured;（8）Other researchers don't agree to join this study.