To compare prehabilitation with physical exercise, psychological support, nutritional support and smoke/alchol stop to "standard of care" before canceer surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
90
prehabilitation
No intervention
6 minute walk test (6mwt)
6 minute walk test (6mwt)
Time frame: 12 weeks
30 s chair stand test
30 s chair stand test
Time frame: 12 weeks
Test of hand grip strength
Test of hand grip strength
Time frame: 12 weeks
International Physical Activity Questionnaire
International Physical Activity Questionnaire
Time frame: 12 weeks
Cardiopulmonary exercise test with ventilatory gas analysis
Cardiopulmonary exercise test with ventilatory gas analysis making it possible to calculate VOmax as well as other established measures of cardiopulmonary function
Time frame: 12 weeks
The presence of malnutrition evaluated with the Global Leadership Initiative on Malnutrition (GLM) criteria
The presence of malnutrition evaluated with the Global Leadership Initiative on Malnutrition (GLM) criteria
Time frame: 12 weeks
Appetite and eating behavior is evaluated with Eating Symptom Questionnaire (ESQ)
Appetite and eating behavior is evaluated with Eating Symptom Questionnaire (ESQ)
Time frame: 12 weeks
Appetite and eating behavior is evaluated with Disease Related Appetite Questionnaire (DRAQ)
Appetite and eating behavior is evaluated with Disease Related Appetite Questionnaire (DRAQ)
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Time frame: 12 weeks
4-week point prevalence of smoking abstinence (among baseline smokers)
4-week point prevalence of smoking abstinence (among baseline smokers), measured with Fagerstroms scale
Time frame: 12 weeks
Weekly alcohol consumption
Weekly alcohol consumption as reported in standard units
Time frame: 12 weeks
Episodes of heavy drinking per month
Episodes of heavy drinking per month as reported in standard units at a single occation
Time frame: 12 weeks
The most severe complication occurring
The most severe complication occurring (according to the Clavien-Dindo scale) until 90 days after surgery
Time frame: 90d after surgery
Sum of all complications in each patient (comprehensive complication index, CCI)
Sum of all complications in each patient (comprehensive complication index, CCI) occuring up to 90 days after surgery
Time frame: 90d after surgery
Length of hospitalization
Length of hospitalization
Time frame: 90d after surgery
Time to functional recovery of physical status as compared to baseline values
Defined as number of days after surgery until the patient has reached all of the following: being mobile at the preoperative level, having sufficient pain control with only oral or transdermal medication, being able to maintain food intake without intravenous fluids and not being in need of intravenous medications
Time frame: 90d after surgery
Clinical Frailty Scale
Clinical Frailty Scale
Time frame: 12 weeks
Grade of sarcopenia
Grade of sarcopenia
Time frame: 12 weeks
The frequency of failures to go through the full treatment program as planned at the first MDT (including, but not limited to, the full oncological chemotherapy program, radiation treatment and final surgery)
The frequency of failures to go through the full treatment program as planned at the first MDT (including, but not limited to, the full oncological chemotherapy program, radiation treatment and final surgery)
Time frame: 90 days
Time from surgery until the day of first dose of adjuvant chemotherapy (among liver and rectal cancer patients for whom postoperative chemotherapy is planned)
Time from surgery until the day of first dose of adjuvant chemotherapy (among liver and rectal cancer patients for whom postoperative chemotherapy is planned)
Time frame: 90 day after surgery
Proportion of patients not able to receive all treatment despite no dissemination of disease
Proportion of patients not able to receive all treatment despite no dissemination of disease
Time frame: 90 day after surgery
Overall survival
Overall survival
Time frame: 5 years
Quality of Life (QoL)
Quality of Life (QoL)
Time frame: 2 years after surgery
Incremental cost-effectiveness ratio
Incremental cost-effectiveness ratio, calculated as the median cost divided by the quality adjusted life years obtained until 2 years after surgery
Time frame: 2 years after surgery