To investigate whether the use of haemoadsorption (HA) on cardiopulmonary bypass during heart transplantation (HTX) has an effect on circulating cytokine levels for the first 120 hours after HTX and induces a decreased inflammatory response, increased anti-inflammatory response or immunosuppressive response. Additionally, the influence of HA on primary graft dysfunction, postoperative cerebral dysfunction, postoperative fluid accumulation, renal dysfunction, duration of mechanical ventilation, length of ICU-stay and 30-day mortality should be investigated
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
Polymer based adsorber system for the elimination of cytokines
Divison of Cardiac Thoracic Vascular Anaesthesia and Intensive Care, Medical University of Vienna
Vienna, Vienna, Austria
RECRUITINGDifference in maximal cytokine peak levels (IL-1β, IL-6, IL-33, TNF-α, IL-10)
Difference in maximal cytokine peak levels in various cytokine levels compared to baseline measured by ELISA
Time frame: 5 days
Difference of immunosuppression (TTV)
Individual immunosuppression measured by Torque-teno-virus load
Time frame: 30days
Difference of immunosuppression (sST2)
Individual immunosuppression measured by sST2 levels
Time frame: 30days
primary graft dysfunction score
Differences in primary graft dysfunction score between both groups
Time frame: 7 days
30-day mortality
Differences in 30-day mortality between both groups
Time frame: 30 days
Mechanical Ventilation
Differences in length of mechanical ventilation
Time frame: up to 4 weeks
Delirium
Differences in Confusion assessment method for the ICU between both groups
Time frame: 5 days
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