Effect of Intracameral Steroids During Phacoemulsification on the Cornea

Cairo University69 enrolled

Overview

Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids. Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal edema and spared corneal endothelium.

Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count. Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids. On the first postoperative day corneal edema in control compared to dexamethasone and TA groups respectively. One month later, the mean increase of corneal thickness in control compared to intracameral dexamethasone and TA groups, respectively. mean endothelial cell loss in control compared to intracameral dexamethasone and TA groups respectively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Corneal Edema

Interventions

Control groupOTHER

23 eyes that didn't receive any intraoperative steroids

Dexamethasone groupDRUG

23 eyes each received intracameral dexamethasone at the conclusion of phacoemulsification Received intracameral 0.4 mg in / 0.1 ml dexamethasone (8mg/2ml®; Amriya or Epico) at the end of phacoemulsification.

Triamcinolone (TA) groupDRUG

23 eyes each received intracameral triamcinolone (TA) at the conclusion of phacoemulsification Received intracameral 2 mg/0.05 ml triamcinolone (TA) (Kenacort-A®; Bristol-Myers Squibb) at the end of phacoemulsification.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cataract grades 2 to 5 nuclear cataract (LOCS III scale) * uneventful phacoemulsification operation Exclusion Criteria: * extremely hard cataract grade 6 nuclear cataract (LOCS III scale) * soft cataract * subluxated lenses or zonular dehiscence * associated ocular pathology such as glaucoma * any signs of uveitis * trauma * retinal detachment * vitrectomized or silicone filled eyes * corneal disease such as Fuch's dystrophy, corneal opacity * previous refractive corneal surgery * Cases that developed ruptured posterior capsule and vitreous loss * those lost to follow up were excluded and randomly replaced by the next chronological patient

Locations (1)

Khaled G Abueleinen

Giza, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

Corneal edema

Clinical grade of corneal edema on the first postoperative day

Time frame: First day postoperative

Central corneal thickness (CCT)

Central corneal thickness in microns after phacoemulsification that was compared to preoperative values

Time frame: Three months

Endothelial cell loss

Corneal endothelial cell count (cell/ square mm) after phacoemulsification that was compared to preoperative values

Time frame: Three months

Secondary Outcomes

IOP

Intraocular pressure in mmHg rise after after phacoemulsification

Time frame: Three months

Data from ClinicalTrials.gov

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