Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder

Inclusion Criteria: * Provide written, voluntary informed consent prior to study enrollment. * Male or female between the ages of 21 to 65. * Patient must be diagnosed with a moderate to a severe depressive episode, as determined by the MADRS score \>21. * Prior to taking part in the trial, all patients were requested to abstain from all psychotropic and anti-inflammatory medications for at least four weeks. Exclusion Criteria: * Current psychotic symptoms or perceptual problems of any kind, at the discretion of the investigator * The presence of a contraindication to PTX, such as a drug allergy or xanthine derivative allergy * The presence of cardiovascular diseases, including high blood pressure, a recent myocardial infarction, cardiac arrhythmia, coronary artery disease, or a coagulation disorder * Renal impairment, defined as creatinine clearance less than 80ml/min * Patients who have previously received electroconvulsive therapy (ECT) * Patients who have inflammatory disorders * Patients with a concurrent active medical condition * Patients with a history of seizures * Patients who are pregnant or nursing females. * Patients with bipolar I or bipolar II disorder * Patients with personality disorders * Patients with eating disorders * Patients with substance dependence or abuse