Periodontitis is an infectious disease defined by bacteria-mediated inflammation of the supporting tissues of the teeth that if left untreated may ultimately lead to the destruction of the attachment apparatus, culminating in tooth loss. Rheumatoid arthritis is a chronic destructive inflammatory disease characterized by autoantibodies and the accumulation and persistence of an inflammatory infiltrate in the synovial membrane that leads to synovitis and the destruction of the joint architecture. The objective of this study was to evaluate the possible beneficial additional value of non-surgical periodontal therapy on systemic markers of inflammation and clinical and serological parameters of rheumatoid arthritis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
30
University of Pisa
Pisa, Italy
Disease Activity Score 28 (DAS-28)
Variation of DAS-28 90 days after periodontal treatment
Time frame: 90 days
Erythrocyte Sedimentation Rate (ESR)
Variation of ESR 90 days after periodontal treatment
Time frame: 90 days
C-Reactive Protein (CRP)
Variation of CRP 90 days after periodontal treatment
Time frame: 90 days
Interleuchin-6 concentration (IL-6)
Variation of IL-6 90 days after periodontal treatment
Time frame: 90 days
Oral Health Related Quality of Life (OHRQoL)
Variation of OHRQoL 90 days after periodontal treatment
Time frame: 90 days
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