The aim of the study is to determine the preferred oximeter averaging setting during automated control of FiO2 (A-FiO2) in infants receiving respiratory support and supplemental oxygen.
There are 7 different averaging time settings available with PRICO (Acutronic Medical Systems AG, Hirzel, Switzerland), but after over a year of experience there is no clear clinical impression of the best setting. Therefore, a small systematic study is needed to determine the optimal guidelines.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
10
The SpO2 averaging time will be set to 4to6 s for the next 12 hours.
The SpO2 averaging time will be set to 10 s for the next 12 hours.
Motol University Hospital
Prague, Czechia
Percent time in SpO2 target range
Percent time in the intended SpO2 target range (compliance), at SpO2 \<86% (safety), and at SpO2 \>98% (safety). Period with SpO2 higher than the target range with FiO2 =0.21 will be included in the target range compliance and excluded from time above the target range.
Time frame: 20 days of intervention on average
Effect of set SpO2 target range and mode of ventilation on the percent time in SpO2 target range, at SpO2 <86%, and at SpO2 >98%.
A general linear model will be used controlling for target range (based on gestational age), mode of ventilation (e.g. High-frequency oscillatory ventilation, Continuous mandatory ventilation, Continuous positive airway pressure, High-flow nasal cannula, and Nasal intermittent positive pressure ventilation), and subject.
Time frame: 20 days of intervention on average
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The SpO2 averaging time will be set to 16 s for the next 12 hours.