Effects of Plant Based Lipids on Glucose Regulation and Cognitive Variables

Lund University17 enrolled

Overview

The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on acute postprandial glucose regulation of plant based lipids. Due to the tight connection between cardiometabolic health and cognitive functions, a secondary issue is to investigate effects of test foods on cognitive test variables and mood parameters.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Diabete Type 2 Obesity

Interventions

lipidsDIETARY_SUPPLEMENT

Investigations of dose-response effects of 3 different doses of an bioactive plant based lipid consumed at breakfast, after overnight fasting. Total amounts of lipids in each test portion are 15g, and the lower doses are supplemented with a control lipid to sum upp to 15 g total lipids. A control product with15g control lipids and without active lipids is also included. The lipids are supplemented to a white wheat bread, corresponding to 50 g available starch. A White wheat bread portion without lipid supplementation is included as a well studied reference product.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Apparently healthy subjects * Between 20 and 40 years old * Body mass index between 19-28 kg / m2), * Consuming a non-vegetarian diet generally in line with the Nordic nutrition recommendations. Exclusion Criteria: * Fasting blood glucose concentration \>6.1 mmol/L * Known metabolic or gastrointestinal disorder (eg diabetes, high cholesterol, high blood pressure, IBS), or other disease that may affect the study results. * Regular medication, except for long-term and stable medication for the lack or reduced production of thyroid hormone (eg Levaxin). * Antibiotics or probiotics for at least four weeks before the start of the study, * The use of tobacco products

Locations (2)

Anne Nilsson

Lund, Välj..., Sweden

The Human Trial Facility, Food Technology engineering and Nutrition, Lund University

Lund, Välj..., Sweden

Outcomes

Primary Outcomes

glucose tolerance

Postprandial blood glucose responses

Time frame: 3 hours. Fasting (time =0), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes

Secondary Outcomes

Insulin responses

Postprandial insulin responses

Time frame: 3 hours. Fasting (time =0 minutes), 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes

Mood variables

Registration of subjective mood ratings (valence and activity) on 0-100 mm Visual Analogue Scales (VAS) at fasting and thereafter every hour until 180 min. Extremes of the sensations of the variables is at the two ends of the scales, i.e. 0 mm relates to the extrem of low senations sensations and 100 mm correspond to the highest sensation of the variables.

Time frame: 60 minutes after start of test product, after 120 minutes and after 180 minutes

Appetite sensations

Subjective sensations of hunger, satiety, and desire to eat are registered on 0-100 mm VAS scales. Extremes of the sensations of the variables is at the two ends of the scales, i.e. 0 mm relates to the extrem of low senations sensations and 100 mm correspond to the highest sensation of the variables.

Time frame: 3 hours. Fasting (time =0), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes

Data from ClinicalTrials.gov

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