The study is an observational prospective evaluation of an approved and unchanged clinical management, evaluating different diagnosis methods to assess brain perfusion in patients with an aneurysmal or AVM-related intracranial hemorrhage
The study is a prospective description and evaluation of an approved and unchanged clinical management, evaluating already used different diagnosis methods to assess brain perfusion in patients with atraumatic (aneurysmal, AVM-related, unknown cause) intracranial hemorrhage.
Study Type
OBSERVATIONAL
Enrollment
100
This study will use an established local protocol for DCI and intracranial arterial vasospastic stenosis screening, and follow-up to make sure that all patients have the same protocol and don't lose any chance of improvement and good outcome : CT perfusion at different time intervals
Erasme Hospital
Brussels, Belgium
RECRUITINGChange in brain hypoperfusion
Brain hypoperfusion in arterial territories assessed by the delays on perfusion Time to drain (seconds) on CT and/or MR perfusion
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Change in vessel size
Change in the vessel size measured on digital subtraction angiography (DSA) and computed tomography angiogram (CTA) in millimeters
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Time to next endovascular intervention for vasospastic stenosis
Delay between two procedures for the same indication
Time frame: Number of days after the endovascular procedure until the next procedure in days, up to 4 weeks
Transcranial Doppler
Reduction in intracranial vasospasm assessed by the targeted vessel velocity in meters per second
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Brain Hypoperfusion 2
Reduction in brain hypoperfusion assessed by the volumes on different perfusion parameters time to peak (in seconds) on CT and/or MR perfusion
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Change in Glasgow coma scale
Glasgow coma scale (GCS between 3 and 15, a higher score means a better outcome)
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Change in National Institutes of Health Stroke Scale score
National Institutes of Health Stroke Scale (NIHSS between 0 and 42, a higher score means a worse outcome)
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Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Change in the monitoring of tissue oxygen pressure (PtiO2)
Monitoring of tissue oxygen pressure (PtiO2)
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Change in the number of new ischemic lesions
Number of new ischemic lesions on non-contrast CT scan
Time frame: Change between day 0, 5, 9, 21 after Intracranial Hemorrhage
modified Rankin Scale at 3 months
clinical evolution (mRS between 0 and 6, a higher score means a worse outcome)
Time frame: 3 months after Intracranial Hemorrhage
Change in brain hypoperfusion 3
Brain hypoperfusion in arterial territories assessed by the delays on perfusion parameters TMax maps in seconds on CT and/or MR perfusion
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage
Change in brain hypoperfusion 4
Brain hypoperfusion in arterial territories assessed by the delays on perfusion parameters Mean transit time on CT and/or MR perfusion in seconds
Time frame: Change between day 0, 5, 9 after Intracranial Hemorrhage