Cardiovascular Risk After Preeclampsia

Charite University, Berlin, Germany60 enrolled

Overview

Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation end products, flow-mediated dilation or pulse wave analysis in comparison to women after healthy pregnancies.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preeclampsia

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women * 18-60 years * 5-15 years postpartum Exclusion Criteria: * Atrioventricular block, chronic obstructive pulmonary disease, bronchial asthma * Pregnancy and/or active breastfeeding * Glaucoma disease, epilepsy * In addition for MRI: metal implants, electric devices, intolerance of contrast media, claustrophobia, renal or hepatic dysfunction (GFR \< 30 ml/min)

Locations (1)

Experimental and Clinical Research Center

Berlin, Germany

RECRUITING

Outcomes

Primary Outcomes

Myocardial perfusion

Measured by adenosine stress Magnetic Resonance Imaging (ml/min/g)

Time frame: Day 2

Secondary Outcomes

Cardiac fibrosis

Measured by Magnetic Resonance Imaging (g)

Time frame: Day 2

Immune cell phenotypes

Measured in isolated peripheral blood mononuclear cells

Time frame: Day 1

Concentration of N-terminal prohormone of brain natriuretic peptide

Measured in serum (ng/l)

Time frame: Day 1

Concentration of brain natriuretic peptide

Measured in serum (ng/l)

Time frame: Day 1

Urinary protein

Measured in spot urine (mg)

Time frame: Day 1

Advanced glycation end products

Measured by skin autofluorescence (arbitrary units)

Time frame: Day 1

Body fat mass

Measured by bioimpedance analysis (%)

Time frame: Day 1

Body fat-free mass

Measured by bioimpedance analysis (%)

Time frame: Day 1

Hand grip strength

Central Contacts

Kristin Kräker, PhD

CONTACT

+49 30 450540 328 kristin.kraeker@charite.de

Data from ClinicalTrials.gov

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