Regular Home Use of Dual-light Photodynamic Therapy in the Management of Chronic Periodontitis

Inclusion Criteria: * Periodontal disease stage I-III, according to criteria the American Academy of Periodontology (AAP) with at least 2 mm interdental CAL in the site of greatest loss * Age of 18-85 years * Presence of \> 20 teeth * Agreement to participate in the study and to sign a written consent form Exclusion Criteria: * Untreated/uncontrollable diabetes mellitus (DM) with HbA1c \>7%, and HbA1c \> 8 if insulin treated DM * Any systemic disease (e.g., wound healing dysfunctions) that could alter the progression of periodontal disease * Use of medicine that would affect the periodontal tissue within the last 6 months (antibiotics, anti-inflammatories, anticonvulsants, immunosuppressants, or calcium channel blockers, including doxycycline, bisphosphonates and chlorhexidine) * Periodontal treatment during the previous 3 months * Allergic to the photosensitizer * Presence of major physical limitation or restriction that prohibit the hygiene procedures used in the study protocol * Removable major prosthesis or major orthodontic appliance * Active smoking, or habitual use of smokeless tobacco products * Pregnancy or lactation * A need for a hopeless teeth extraction, or open cavities in need for immediate endodontic treatment