This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.
Exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. Various training options depending on various physical circumstances will be presented. However, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. In general, 3-6 months of frequent exercise can enhance physical and cognitive outcome. The investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. This study designed to recruit 200 older adults with frailty. All the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. Outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
200
using either elastic band, dumbbells, treadmill, cycling, machines for 6 months
Department of Physical Medicine & Rehabilitation, Taipei Veterans General Hospital, Yuan-Shan/Su-Ao Branch
Yilan, Taiwan
RECRUITINGChange of Barthel index
Test function of activities of daily living, range from 0-100, higher values represent a greater outcome.
Time frame: Up to 6 months
Change of Montreal Cognitive Assessment
Test cognition including memory, attention, and language, range from 0-30, higher values represent a greater outcome
Time frame: Up to 6 months
Change of Geriatric Depression Scale
Test depression status, , range from 0-15, higher values represent a worse outcome
Time frame: Up to 6 months
Change of Lawton Instrumental Activities of Daily Living (IADL) Scale
To assesses a person's ability to perform tasks such as using a telephone, doing laundry, and handling finances.y. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent)
Time frame: Up to 6 months
Change of Six-minute Walking Test
Test physical function. In healthy subjects, the 6-min walk distance ranges from 400 to 700 m.
Time frame: Up to 6 months
Change of Timed Get-up-and-go Test
Test for quantifying functional mobility
Time frame: Up to 6 months
Change of Memory span test
an examiner reads a list of random numbers aloud at about the rate of one number per second. At the end, the person being tested is asked to recall the items, in order.
Time frame: Up to 6 months
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Change of Color Trails Test
Test cognitive function. Test is scored by how long it takes to complete the test.
Time frame: Up to 6 months
Change of Digit symbol substitution test
Test cognitive function. The test consists of filling as many empty boxes as possible with a symbol matching each number. The score is the number of correct number-symbol matches achieved.
Time frame: Up to 6 months
Change of Mini-mental state examination
Test cognitive function, range from 0-30, higher values represent a greater outcome
Time frame: Up to 6 months