Immune Effects of Vedolizumab With or Without Anti-TNF Pre-treatment in T1D

Inclusion Criteria: 1. Males and females 18-45 years of age, inclusive 2. Diagnosis of T1D between 21 days and 3 years from screening 3. Positive for at least one diabetes-related autoantibody any time since diagnosis, including but not limited to: * Glutamate decarboxylase (GAD-65) * mIAA, if obtained within 10 days of the onset of exogenous insulin therapy * IA-2 * ZnT8 (Zinc transporter 8) 4. Random (non-fasting) C-peptide or peak MMTT stimulated C-peptide ≥ 0.2 pmol/mL. 5. Females of child-bearing potential must be willing to use effective birth control from the screening visit through 12 weeks post last dose of study medication. 6. Up to date for clinically recommended immunizations including COVID-19 and seasonal influenza vaccine at least 3 weeks prior to baseline treatment. 7. Willing to forgo live vaccines 6 weeks prior to baseline treatment visit until 6 weeks following last treatment visit. 8. HbA1c ≤ 8.5% at screening 9. Willing and able to give informed consent for participation Exclusion Criteria: 1. History of severe reaction or anaphylaxis to human, humanized or murine monoclonal antibodies 2. History of malignancy or serious uncontrolled cardiovascular, nervous system, pulmonary, renal, or gastrointestinal disease 3. History of immunodeficiency 4. Recent (within 3 months) serious bacterial, viral, fungal, or other infections 5. Pending or positive SARS-CoV-2 test or symptoms of possible COVID-19 illness at baseline treatment visit. 6. Serologic evidence of current or past HIV, Hepatitis B, or Hepatitis C. 7. Positive QuantiFERON or PPD TB test, history of tuberculosis, or active TB infection. 8. Active infection with EBV as defined by real-time polymerase chain reaction (PCR). 9. Active infection with CMV as defined by real-time PCR. 10. Clinically significant liver function abnormalities as defined by ALT or AST\> 1.5 x the upper limit of age-determined normal (ULN). 11. Any of the following hematologic abnormalities: * White blood count \<3,000/μL or \>14,000/μL * Lymphocyte count \<800/μL * Platelet count \<75,000 /μL * Hemoglobin \<10.0 g/dL * Neutrophil count \<1500 cells/μL 12. Females who are pregnant or lactating. 13. Receipt of live vaccine (e.g., varicella, MMR (measles, mumps and rubella), intranasal influenza vaccine) within 6 weeks of randomization. 14. Receipt of other vaccines within 3 weeks of baseline treatment. 15. Receipt of an immune modulating biologic or investigational drug within 3 months or 5 half-lives before screening visit. 16. Use of non-insulin therapies aimed to control hyperglycemia within 30 days of screening visit. 17. History of other clinically significant autoimmune disease needing chronic therapy with biologics or steroids with the exception of celiac disease and stable thyroid disease. 18. Use of medications known to influence glucose tolerance. Topical, nasal, inhaled corticosteroids acceptable per investigator discretion. 19. Any medical or psychological condition that in the opinion of the principal investigator would interfere with the safe completion of the trial.