A phase4 Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B

Inclusion Criteria: 1. As of the date of written consent, adults aged 19 or above 2. Patients with chronic hepatitis B 3. For chronic hepatitis B, Viread Tab. monotherapy† for more than 48 weeks, HBV suppression‡(virologic suppression) was confirmed, and it was determined that Tenofovir monotherapy for more than 48 weeks would be required. † However, patients who take Viread Tab for more than 48 weeks before screening but do not take Viread Tab at the time of screening and discontinue the administration within 4 weeks until the time of randomization can be registered. (treatment gap ≤ 28 days) * HBV DNA \< 400 copies/mL (=69 IU/mL\*) \* IU/mL is converting to copies/mL by unit for each institution. (Ex: 5.8 copies/mL = 1 IU/mL) 4. Subject who voluntarily consents to participate in the clinical trial and signs an informed consent Exclusion Criteria: 1. Patients with liver cancer or decompensated liver cirrhosis\* \*Cirrhosis with clinical signs/symptoms of decompensation (jaundice, ascites, variceal bleeding, hepatic coma) 2. Patients with Hepatitis C virus (HCV), human immunodeficiency virus (HIV) with overlapping infections (HCV Ab positive, HIV Ab positive) However, if the HCV Ab or HIV Ab test result is judged to be 'false positive' by the investigator, HCV or HIV infection can be confirmed through additional confirmatory tests (HCV, HIV RNA test), etc. 3. Patients with other clinically significant liver disease (Hemochromatosis, Wilson's disease, Alcoholic liver disease, Autoimmune hepatitis, α-1 antitrypsin deficiency) 4. Patients confirmed by laboratory test results as followings * Severe anemia: Hemoglobin \< 8g/dL ② Inadequate renal function: eGFR (Ccr, Cockcroft-Gault formula) \< 50 mL/min ③ Inadequate hepatic function: * Total bilirubin \> 3.0 mg/dL * Albumin \< 2.8 mg/dL * Prothrombin Time(PT) \> INR 2.2 5. Patients with malignant tumors diagnosed within 5 years prior to screening However, in the case of basal cell carcinoma or squamouscell carcinoma of the skin, it is possible to participate in the clinical trial if it is judged to be 'cured' at the discretion of the investigator after surgery (treatment),. 6. Patients who are scheduled for an organ transplantation or who have undergone organ transplantation surgery 7. Patients with a history of clinically significant neuropsychiatric disorders, alcoholism, or drug dependence 8. Patients known to have hypersensitivity or allergy to components of investigational products or similar drugs 9. Patients who administered immunosuppressive drugs within 24 weeks prior to screening or who administered systemic corticosteroids over a limited dose (equivalent to prednisolone 10 mg/day) for 4 consecutive weeks or more. 10. Patients who are expected to require administration of the following drugs during the clinical trial period ① Immunosuppressive drug ② Systemic corticosteroids above a limited dose (equivalent to prednisolone 10 mg/day) for 2 consecutive weeks or more ③ Drugs affecting renal excretion, drugs inducing nephrotoxicity or hepatotoxicity ④ Anti-HBV drugs other than Tenofovir (ex. emtricitabine, lamivudine, telbivudine, clevudine, entecavir, interferone) ⑤ Patients who administered hepatotonics at a stable dose for more than 3 months before screening can be registered. 11. Those who have a history of fractures requiring bone mineral density (BMD) monitoring or are at risk of osteopenia, who are judged unable to participate in clinical trials according to the investigator's judgment 12. For pregnant, lactating and reproductive women, patients who do not consent to contraception by a medically accepted method (surgical sterilization, intrauterine device, condom or diaphragm) during the clinical trial period 13. Patients who participated in another clinical trial within 12 weeks prior to screening and received investigational drugs or investigational devices. 14. In addition to the above, subject considered ineligible to participate in this study by the investigator.