Clinical Observational Registry of Patients With Left Bundle Branch Block

Azienda Ospedaliero Universitaria di Sassari1,000 enrolled

Overview

The electromechanical dyssynchrony induced by the presence of LBBB is in some patients, but not all, the cause of progressive left ventricular systolic dysfunction and heart failure. Aims 1. To investigate the clinical, ECG, imaging-derived features in a large cohort of patients affected by LBBB on ECG. 2. To identify predictors of LBBB-induced LV systolic dysfunction and predictors of outcome in this population. 3. To derive data which may have an impact on therapeutic management.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Left Bundle Branch Block (LBBB) on ECG

Interventions

ECG, Echocardiogram, Magnetic resonanceDIAGNOSTIC_TEST

Clinical and instrumental follow-up

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * LBBB on ECG Exclusion Criteria: * Previous extensive anterior myocardial infarction * Previous cardiac surgery or transcatheter aortic valve implantation (TAVI) * Congenital structural heart disease * Patients implanted with permanent right ventricular stimulation devices and permanent pacing * Denial to consent

Outcomes

Primary Outcomes

Left ventricular dysfunction

Echocardiographic left ventricular ejection fraction - EF (%)

Time frame: 20 years

Secondary Outcomes

Adverse cardiovascular events (e.g., heart failure)

Heart failure (incidence and prevalence) Hospitalizations due to heart failure MACE

Time frame: 20 years

Central Contacts

Giuseppe D Sanna, MD PhD

CONTACT

+39 0792061561 giuseppe.sanna@aousassari.it