The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome at UZ Brussel hospital (UZB).
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome. These includes: 1. demographical data: age, sex 2. antropometric data: height, weight, BMI 3. clinical data: comorbidities, arrhythmias, PM or ICD implantation, therapy 3\) data on the families: number of family members, sudden death history. 4) data on the genetics 5) data on: ECG, echocardiography, CT scan, MRI of heart, MRI of brain, ECG imaging, 3D electroanatomical mapping and ablation
Study Type
OBSERVATIONAL
Enrollment
2,000
UZ Brussel Heart Rhythm Management Center
Brussels, Belgium
RECRUITINGVentricular arrhythmias
Composite of: sudden cardiac death, aborted sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, ICD appropriate therapy
Time frame: through study completion, an average of 10 year
Atrial fibrillation
Atrial fibrillation occurrence
Time frame: through study completion, an average of 10 year
Death for any cause
Death for any cause
Time frame: through study completion, an average of 10 year
Cardiovascular death
Death for cardiovascular cause
Time frame: through study completion, an average of 10 year
Genetic mutations
Genetic mutations (pathogenic and variant of unknown significance) associated with Brugada syndrome. Wide gene panel with next generation sequencing will be used: Roche SeqCap® EZ Human Exome Probes v3.0 for BrS.
Time frame: Baseline
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