Excimer Light in Psoriasis

Cairo University40 enrolled

Overview

The aim of this study is to determine the standard tissue levels of SP and its receptor in lesional skin of psoriasis patients in both developing and stationary stages before and after excimer light therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Psoriasis

Interventions

Excimer lightDEVICE

Excimer light sessions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Type of Psoriasis: plaque psoriasis. * Less than 10% surface area. Exclusion Criteria: * Erythrodermic psoriasis * Pustular psoriasis * Topical treatment for psoriasis for the past 2 weeks. * Systemic retinoids in the last 2 years. * Systemic treatments (including any drugs that affect SP level as Aprepitant) in the last 3 months. * Contraindications to excimer light therapy (history of skin malignancy or precancerous conditions like xeroderma pigmentosum or photosensitivity)

Locations (1)

Kasr Al Ainy Faculty of medicine

Cairo, Egypt

Outcomes

Primary Outcomes

Excimer laser efficiency in active and stable psoriasis

Determine the clinical improvement using Local psoriasis severity index

Time frame: through study completion, an average of 6 months

Excimer laser efficiency on neurogenic inflammation

level of affection of the neurogenic inflammation in psoriasis lesions after using Excimer light therapy. Determine substance P and its receptor levels before and after therapy.

Time frame: through study completion, an average of 6 months

Data from ClinicalTrials.gov

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