Pentoxifylline in Treatment of Patients With Nonalcoholic Steatohepatitis

Inclusion Criteria: 1. Aged between 18- 60 years old. 2. Both sexes 3. Patients who have nonalcoholic steatohepatitis (NASH) will be diagnosed by 1. clinical examination (obese, high body mass index). 2. radiological criteria of fatty liver (abdominal ultrasonography). 3. laboratory investigation (elevated liver enzymes aspartate transaminase (AST), alanine transaminase (ALT). 4. The ability to give informed consent 5. Appropriate exclusion of other liver diseases Exclusion Criteria: 1- Patients with other diagnosed chronic liver diseases as viral hepatitis, metabolic and genetic disorders as Hemochromatosis, Wilson disease, autoimmune hepatitis and drug induced liver disease as well as patients with recent infection and those who refused to be entitled in the study. 2\. Patients will be excluded if they had a history of past excessive alcohol drinking for a period longer than 2 years at any time in the past 10 years. 3\. Patients also will be excluded if they take medications known to cause steatosis or taking medications that have shown benefits in previous NASH pilot studies, including vitamin E, , thiazolidinedione, and alpha-glucosidase inhibitors. 4\. Patients with a history of hypersensitivity to PTX or the methylxanthines (caffeine, theophylline, and theobromine) will be excluded, as well as those with a history of cerebral