NCT05286151 - Network Connectivity and Temporal Processing in Adolescents Who Stutter | Crick

Overview

The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).

Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

500

Conditions

Stuttering, Childhood Stuttering

Interventions

Rhythm discriminationBEHAVIORAL

Participants will complete a rhythm discrimination task once per year for 3 years.

Eligibility

Sex: ALLMin age: 9 YearsMax age: 13 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria Children who stutter: * English as primary language * Current or past stuttering diagnosis Inclusion Criteria Children who do not stutter: * English as primary language Exclusion Criteria Children who stutter: * Diagnosed/under treatment for any neurological or psychiatric conditions * Head trauma with loss of consciousness * Major medical illness * Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments) * Face, motor, or reflex abnormalities Exclusion Criteria Children who do not stutter: * Personal or family history of stuttering * Diagnosed/under treatment for any neurological or psychiatric conditions * Head trauma with loss of consciousness * Major medical illness * Hearing loss * Language/motor delay (below -2 standard deviations on standardized assessments * Face, motor, or reflex abnormalities

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

RECRUITING

Outcomes

Primary Outcomes

Rhythm discrimination (d')

Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

Time frame: Year 1

Rhythm discrimination (d')

Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

Time frame: Year 2

Rhythm discrimination (d')

Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).

Time frame: Year 3

Central Contacts

Soo-Eun Chang, PhD

CONTACT

734-232-0300 sooeunc@umich.edu

Emily Garnett, PhD

CONTACT

734-232-3371 emilyog@umich.edu