Hormonal milieu during implantation is crucial to embryo-endometrium interaction and to the viability of the conceptus. Alterations in the peri-implantation environment are considered to impair perinatal outcomes in intracytoplasmic sperm injection (ICSI) therapy. GnRH-a is a new and promising modality for LPS. Regimens for using GnRH-a in LPS, including single mid-luteal bolus or the addition of a GnRH-a to progesterone supplementation, have been recently suggested. The aim of this study is to evaluate the impact of addition of mid-luteal single-dose or multiple-dose GnRH agonist to the routine luteal phase support in patients undergoing ICSI cycles using GnRH antagonist protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
75
subcutaneous injection
vaginal suppositories (400 mg twice daily) starting on the day after oocyte retrieval and will be continued till pregnancy assessed by serum β-HCG 15 days after ICSI, and if pregnant, for 10 weeks of gestation.
Alexandria University
Alexandria, Alexandria Governorate, Egypt
Clinical pregnancy rate
Calculated as the number of clinical pregnancies (Presence of an intrauterine gestational sac with embryonic cardiac activity observed by vaginal ultrasound) divided by the number of embryo transfer procedures.
Time frame: 2 weeks after positive pregnancy test
Implantation rate
the ratio of the number of gestational sacs detected by sonography to the total number of embryos transferred.
Time frame: 2 weeks after positive pregnancy test
Multiple pregnancy rate
The percentage of pregnancies with more than one fetus
Time frame: 8 weeks of gestation
Serum β-human chorionic gonadotropin (β-HCG) concentration
In milli-International unit/ml on day 15 after ICSI
Time frame: 15 days after ICSI
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