3D PET Myocardial Blood Flow and Rb82 Infusion Profiles

Inclusion Criteria: Normal Volunteers * Adults ≥18 and \<40 years old able to give informed consent. * Ability to abstain from caffeine for 48 hours The "clinical" population * Adults ≥18 years old able to give informed consent. * Any cardiac risk factor including hypertension, hyperlipidemia, diabetes mellitus or tobacco use OR * CAD defined by with history of PCI or CABG, Coronary Ca score\>400, or dense coronary calcifications noted on chest CT * Ability to abstain from caffeine for 48 hours The "infarct" population * Adults ≥18 years old able to give informed consent. * Prior cardiac PET scan demonstrating a fixed defect ≥ 15% of the LV myocardium with relative uptake ≤60% maximum uptake. * In addition, to the perfusion defect, each volunteer requires either: * FDG PET or MRI viability studies confirming infarct OR * akinesis and wall thinning on ECHO within the same territory as the PET defect in addition to Q-waves on ECG * Ability to abstain from caffeine for 48 hours Exclusion Criteria: Normal Volunteers * Any chronic cardiac disease or condition (e.g., hypertension, hyperlipidemia) * Any chronic systemic disease or condition (e.g., diabetes, systemic lupus, rheumatoid arthritis) * Tobacco use * Family history in a first degree relative with clinical CAD (h/o PCI, MI or CABG) in men \<55 or women \<65 * Severe claustrophobia * Positive urine pregnancy test * Inability to give informed consent * BMI ≥ 30 or BMI\>25 and \<30 provided waist to hip ratio \>0.80 in women or 0.90 in men. The "clinical" and "infarct" populations * Severe claustrophobia * Hemodynamic instability or unstable symptoms * Positive urine pregnancy test * Inability to give informed consent