Single Ascending Dose Study of ANX105

Key Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, and laboratory tests. * Have been fully vaccinated with SARS-CoV-2 vaccination according to local guidelines within 14 days prior to Day -1. * Documented history of vaccinations within 5 years or willing to undergo vaccinations prior to screening visit against encapsulated bacterial pathogens. Key Exclusion Criteria: * Clinically significant infection within 30 days prior to Day -1 that required medical intervention. * Significant allergies to humanized monoclonal antibodies. * Use of immunosuppressants including high-dose systemic corticosteroids within 30 days prior to Day -1. * Antinuclear antibodies (ANA) titer ≥1:160 (for either of the 2 ANA results a minimum of 2 weeks apart) at Screening. * Have poor venous access limiting phlebotomy. * Donation or loss of \> 500 milliliter whole blood within 30 days prior to Day 1 or donation of plasma within 14 days prior to Day -1. * Hospitalization during the 4 weeks prior to Screening.