Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.
Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease "ventilator-asynchrony" in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Midazolam infusion will be given after the surgery as 0.25 mg/kg/min.
Ch. Pervaiz Elahi Institute of Cardiology
Multan, Punjab Province, Pakistan
Duration of post-surgery sedation
Duration of post-surgery sedation following cardiac surgery
Time frame: Time in minutes calculated from end of surgery to the time of awakening up to 24 hours in both study groups
Time taken to post-surgery extubation
Time taken from the end of cardiac surgery to post-surgery extubation
Time frame: Time taken in minutes from the end of the cardiac surgery to post-surgery extubation up to 1 week duration in both study groups
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