Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion

Inclusion Criteria: 1. 18-75 years old; 2. Non-small cell lung cancer with pleural metastasis confirmed by histopathology or cytology; 3. ECOG score 0-1; 4. Cardiopulmonary function can tolerate painless thoracoscopic examination; 5. Patients who underwent medical thoracoscopy for pleural effusion at first diagnosis and underwent medical thoracoscopy cryotherapy at the same time of biopsy were also included in the study. Non-small cell lung cancer was confirmed by pathological results; 6. All subjects or their guardians must sign the informed consent before entering the study. Exclusion Criteria: 1. Expected survival \<2 months; 2. Hemoglobin \<110g/L, white blood cell count \<3×109/L, neutrophil \<2.0×109/L, platelet \<100×109/L; 3. severe cardiac insufficiency, abnormal liver and kidney function (blood test results of transaminase and creatinine \> 1.5 times the normal upper limit); 4. have received chemotherapy or anti-angiogenic drugs (such as bevacizumab, endu, anlotinib, etc.); 5. History of radiotherapy; 6. history of intrathoracic local treatment; 7. multiple serous cavity effusion, or bilateral pleural effusion; 8. patients allergic to erythromycin; 9. the lung cannot be reopened.