Sarcopenia in Children

University Tunis El Manar60 enrolled

Overview

Juvenile idiopathic arthritis (AJI), is a frequent inflammatory disease in children, characterized by pain, arthritis, and deformities. Chronic inflammation leads to physical inactivity and can be associated with muscle weakness around affected joints, low bone strength, and mass(3). To our knowledge, no study has focused on the prevalence of sarcopenia in JIA and the data on the muscle disorder are lacking. The purpose of the present study is to detect sarcopenia and identify associated factors in children with JIA

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcopenia Juvenile Idiopathic Arthritis

Interventions

densitometry/ handgrip dynamometerDIAGNOSTIC_TEST

all patients will undergo the Dual-energy X-ray absorptiometry (DXA) and the muscle strength assessment using the handgrip dynamometer

Eligibility

Sex: ALLMin age: 4 YearsMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * children with juvenile idiopathic arthritis fulfilling the ILAR criteria Exclusion Criteria: * We excluded patients who have a prosthesis, nutritional problems, inflammatory bowel disease, coeliac disease, temporomandibular involvement, or another chronic disease.

Outcomes

Primary Outcomes

skeletal muscle mass

Dual-energy X-ray absorptiometry (DXA) measures the appendicular lean mass ( the sum of the lean mass of the arms and legs) and adjusted to the body mass index

Time frame: 4 months

Secondary Outcomes

muscle strenght

Three consecutive trials will be measured by the handgrip dynamometer between the dominant and non-dominant sides. the highest value will be used and adjusted to the body mass index

Time frame: 5 months

Data from ClinicalTrials.gov

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