Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)

University of Miami223 enrolled

Overview

The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee and hip arthroplasty could be observed with the substitution of Intravenous meloxicam for ketorolac in the current established peri-operative pain protocol and if these changes lead to a decrease in opioid consumption (in morphine equivalents).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

223

Conditions

Total Knee Replacement Total Hip Replacement

Interventions

IV meloxicamDRUG

Participants will be administered meloxicam 30 mg IV push pre-operatively.

KetorolacDRUG

Participants will be treated with ketorolac 15 mg IV push intra-operatively, followed by 15 mg IV push every 6 hours scheduled for 2 doses.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients over the age of 18, 2. Patients undergoing primary total knee or primary total hip replacement at the University of Miami Hospital, 3. Patients that have capacity to provide medical consent Exclusion Criteria: 1. All patients under the age of 18 2. Prisoners, diabetics, increased risk of bleeding, and pregnant women. 3. Patients with prior surgery or history of infection on the joint of interest. 4. Patients with an estimated glomerular filtration rate (eGFR) \<50 ml/min 5. Patients on dialysis or renal transplant. 6. Patients on steroid preoperatively. 7. Allergy to sulfas 8. Inability to provide medical consent. 9. Any condition that, in the opinion of the investigator, would compromise the well-being of the patient or the study or prevent the patient from meeting or performing study requirements will exclude the participant.

Locations (1)

University of Miami

Miami, Florida, United States

Outcomes

Primary Outcomes

Pain Measured by the Numeric Rating Scale

A numeric pain rating scale will be used - a higher pain score would indicate higher pain levels. It is scaled from 0-10.

Time frame: 2 hours postoperatively

Pain Measured by the Numeric Rating Scale

A numeric pain rating scale will be used - a higher pain score would indicate higher pain levels. It is scaled 0-10.

Time frame: 24 hours postoperatively

Secondary Outcomes

Nausea Score as Measured by a Likert Scale

Patients select a score to indicate the severity of their nausea. Scores of 0, 1-2, 3-6, and 7-9 indicate no nausea, mild nausea, moderate nausea, and severe nausea, respectively. The score 10 is assigned to vomiting.

Time frame: 2 hours postoperatively

Nausea Score as Measured by a Likert Scale

Time frame: 24 hours postoperatively

Length of Stay as Measured by Hours in the Hospital

Length of stay for the patient as measured in hours from surgery until the moment of discharge

Time frame: Until patient discharged from the hospital

Length of Stay as Measured by Hospital Nights

The total number of overnights spent in the hospital between surgery and discharge

Time frame: From surgery until discharge

Length of Stay as Measured by Same Day Discharges

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.