A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjects

Inclusion Criteria: * Provision of signed and dated, written informed consent prior to any study specific procedures. * Healthy males or non-pregnant, non-lactating healthy females aged 18 to 55 years at the time of signing informed consent. * Females must have a negative serum pregnancy test at screening and a negative urine pregnancy test on admission to the unit, must not be lactating, confirmed at screening and fulfil the criteria detailed in Section 9.4. * Have a body mass index (BMI) between 18.0 and 30.0 kg/m2 inclusive and weigh at least 50 kg and no more than 100 kg inclusive. * Must be willing and able to communicate and participate in the whole study. * Subjects must have been received both doses of the SARS-CoV-2 vaccine. * Must agree to adhere to the contraception requirements defined in Section 9.4 Exclusion Criteria: * History of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer's ability to participate in the study. * History or presence of any disease or condition known to interfere with absorption, distribution, metabolism, or excretion of drugs. * Evidence of renal impairment at screening, as indicated by an estimated eGFR of \<60 mL/min using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. * A personal or family history of medullary thyroid carcinoma or have multiple endocrine neoplasia syndrome type 2. * Thyroid C-cell hyperplasia (calcitonin level \> 50 ng/L) or medullary thyroid carcinoma at screening. * History of clinically significant cardiovascular, renal, hepatic, dermatological, respirator, neurological, psychiatric or gastrointestinal disease disorder including a history of pancreatitis. * Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of the first administration of IMP. * Any clinically significant abnormalities in clinical chemistry, haematology, or urinalysis results, at screening as judged by the investigator. * Amylase and/or lipase \>1.5 × upper limit of normal (ULN) at screening * Any clinically significant abnormal findings in vital signs, at screening and/or first admission to the study unit, as judged by the investigator. * Any clinically significant abnormalities on 12-lead ECG, including but not limited to QTcF \>450 msec, at screening, as judged by the investigator. * Any positive result on screening for serum hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV Ab), and human immunodeficiency virus (HIV) antibody. * Evidence of current infection with SARS-Cov-2. * Has received another new chemical entity (defined as a compound which has not been approved for marketing) within the 90 days prior to Day 1, or less than 5 elimination half-lives prior to Day 1, whichever is longer. Note: subjects consented and screened, but not randomised in this study or a previous phase I study, are not excluded. * Plasma donation within 1 month of screening or any blood donation/loss more than 500 mL during the 3 months prior to screening. * History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as judged by the investigator or history of hypersensitivity to drugs with a similar chemical structure or class to cotadutide. Hay fever is allowed unless it is active * Current smokers or those who have smoked or used nicotine products (including e-cigarettes) within the 3 months prior to screening. A confirmed breath carbon monoxide reading of greater than 10 ppm at screening or admission. * Positive screen for drugs of abuse at screening or on each admission to the study centre or positive screen for alcohol on each admission to the study centre. * Use of any prescribed or nonprescribed medication including antacids, analgesics (other than paracetamol/acetaminophen, hormonal contraception and hormonal replacement therapy), herbal remedies, megadose vitamins (intake of 20 to 600 times the recommended daily dose) and minerals during the two weeks prior to the first administration of IMP or longer if the medication has a long half-life. Exceptions may apply, as determined by the investigator, if each of the following criteria are met: medication with a short half-life if the washout is such that no pharmacodynamic activity is expected by the time of dosing with IMP; and if the use of medication does not jeopardize the safety of the trial subject; and if the use of medication is not considered to interfere with the objectives of the study * Known or suspected history of alcohol or drug abuse in the past 2 years or excessive intake of alcohol (\>21 units per week for men and \>14 units per week or women \[1 unit = ½ pint beer, or a 25 mL shot of 40% spirit, 1.5 to 2 units = 125 mL glass of wine, depending on type\]) or as judged by the investigator. A confirmed positive alcohol breath test at screening or admission. * Excessive intake of caffeine-containing drinks or food (e.g., coffee, tea, chocolate) as judged by the investigator. Excessive intake of caffeine defined as the regular consumption of more than 600 mg of caffeine per day (e.g., \>5 cups of coffee) or would likely be unable to refrain from the use of caffeine-containing beverages during confinement at the investigational site. * Involvement of any Astra Zeneca, Quotient or study site employee or their close relatives. * Subjects who have previously received cotadutide. * Any subject who has received a GLP-1 analogue containing preparation within the last 30 days or 5 half-lives of the drug (whichever is longer) at the time of screening. * Subjects who do not have suitable veins for multiple venepunctures/cannulation as assessed by the investigator or delegate at screening. * Skin disorder/condition or tattoos in the area of the proposed injection site which can interfere with assessments required by protocol. * Judgment by the investigator that the volunteer should not participate in the study if they have any ongoing or recent (i.e., during the screening period) minor medical complaints that may interfere with the interpretation of study data or are considered unlikely to comply with study procedures, restrictions, and requirements. * Subjects who cannot communicate reliably with the investigator. * Vulnerable subjects, e.g., kept in detention, protected adults under guardianship, trusteeship, or committed to an institution by governmental or juridical order. * Failure to satisfy the investigator of fitness to participate for any other reason.