This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.
Study Type
OBSERVATIONAL
Enrollment
1,000
Data of macular optical coherence tomography (OCT)
University of California San Francisco, Department of Ophthalmology
San Francisco, California, United States
RECRUITINGBascom Palmer Eye Institute
Miami, Florida, United States
RECRUITINGOCT - Central retinal volume
Number of participants with preserved central retinal volume
Time frame: Baseline (about 10 minutes)
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University of Pittsburgh, Department of Ophthalmology
Pittsburgh, Pennsylvania, United States
Beijing Institute of Ophthalmology
Beijing, China
RECRUITINGUniversitätsklinikum Tübingen Augenklinik
Tübingen, Germany
RECRUITINGSemmelweis University, Department of Ophthalmology
Budapest, Hungary
RECRUITINGOculista Ospedale Parma
Parma, Italy
RECRUITINGUniversity Hospital Basel, Eye Clinic
Basel, Switzerland
RECRUITINGMoorfields Eye Hospital
London, United Kingdom
RECRUITING