Does Positive Pressure Extubation Reduce Postoperative Desaturation?

University Hospital, Lille264 enrolled

Overview

Single-center, prospective, controlled, parallel, randomized, single-blind study comparing the conventional extubation technique to two positive pressure extubation techniques on postoperative desaturations

Study realise on university hospital on Lille in France. Patients inclusion is prospective and randomised in three groups. First group : extubation is realised with aspiration in tracheal tube during removal tube Second group : extubation is realised without aspiration but with APL valve set to 20cmH20 Third group : extubation is realised without aspiration but with ventilator parameters were set for PSV mode (inspiratory pressure of 10cmH2O and PEEP identical to that administered in the operating room

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

264

Conditions

Extubation Postoperative Complications Lung Ultrasound Score

Interventions

positive pressure during extubation procedurePROCEDURE

positive pressure during extubation procedure

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Visceral or urological surgery * Scheduled surgery * Surgical or patient requirement: placement of an arterial catheter * Supine position * Post-surgical extubation scheduled in the operating room * Minimum age of 18 years * Informed and signed consent Exclusion Criteria: * Severe obesity (BMI over 35kg/m2) * pregnant woman * Acute or chronic preoperative respiratory pathology. * Sleep apnea syndrome * Inability to receive informed information (does not speak, read or understand French) * Patient under guardianship or curatorship * Lack of social security coverage * History of intubation or criteria for difficult intubation or ventilation.

Locations (1)

Hop Claude Huriez Chu Lille

Lille, France

RECRUITING

Outcomes

Primary Outcomes

desaturations during extubation

saturation \<92%

Time frame: 1 minute after extubation

Secondary Outcomes

desaturation postoperatory

saturation\<92%

Time frame: 5 and 30 minutes after extubation

hypoxemia post operatory

PaO2 \<60mmHg

Time frame: 1 and 30 minutes after extubation

atelectasis

Lung ultrasound score (LUS); min = 0, max = 32, higher scores mean is worse outcome

Time frame: 30 minutes after extubation

awakening time

time in seconds

Time frame: through extubation completion, an average 2 minutes

use of oxygen

days Numbers of oxygen therapy, kinesiotherapy, non invasive ventilation

Time frame: day 7

post operative complications

Clavien Dindo Score; min = grade I, max = grade V; higher scores mean is worse outcome

Time frame: day 7 and day 28

feasibility and acceptance of both techniques pressure positive extubation

questionnaire, min = 4, max =20, higher scores mean is worse outcome

Time frame: 15 minutes after extubation

Central Contacts

Cédric CIRENEI, MD

CONTACT

0320445962 cedric.cirenei@chru-lille.fr

Data from ClinicalTrials.gov

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