Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

Future University in Egypt50 enrolled

Overview

The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls. Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aggressive Periodontitis

Interventions

non surgical periodontal therapyPROCEDURE

Scaling and root planing

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Medically free subjects . * both genders . * age range between 30 to 60 years old . Exclusion Criteria: * Subjects with periodontal surgeries in the last 6 months. * Subjects with prior use of antibiotics in the last 6 months. * Smokers. * Pregnant and lactating females were excluded. * Lactating females.

Locations (1)

Future university in Egypt

Cairo, Egypt

Outcomes

Primary Outcomes

measure levels of Il-17 and Il-18 in chronic periodontitis patients

measure levels of Il-17 and Il-18 in GCF of chronic periodontitis patients

Time frame: Change from Baseline Il-17 andIl-18 at 3 months

Data from ClinicalTrials.gov

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