Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents

Mansoura University45 enrolled

Overview

Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents

Medical management of incipient lesions by application of remineralizing agents like fluoride therapy, amorphous calcium phosphate (ACP), and Casin phosphopeptide amorphous calcium phosphate (CPP-ACP) has proved to be effective in reversing such lesions. Fluoride was considered the "gold standard" remineralizing agent , However several recent researchers found that; the ideal remineralizing agents should diffuse or deliver calcium and phosphate ions into early enamel lesion. Calcium-silicate based material such as β-CaSiO3 and β-Ca2SiO4 play an important role in hard tissue regeneration, showing good bioactivity and biocompatibility and can induce bone like apetite formation in stimulated body fluids. when β-CaSiO3 and β-Ca2SiO4 come in contact with saliva it will be dissolve forming silanol group (Si-O ) on the enamel surface which can bind to Ca ions and inducing the precipitation of hydroxyapatite. In the light of this, this study was designed to compare the remineralization potential of silver diamine flouride/ potassium iodide, casin phosphopeptide amorphous calcium phosphate and experimental tricalcium silicate on early enamel lesions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Enamel Caries

Interventions

Silver diamine fluoride- potassium iodideDRUG

SDF-KI (riva star, SDI.Ltd )was applied ( as a professional application) by micro brush over the early enamel lesions on the buccal surface of molar teeth

Casein phosphopeptide amorphous calcium phosphateDRUG

CPP-ACP (tooth mousse, GC, Matraville Sydney, Australia) was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily. the patients were instructed to leave it for about 3minutes before rinsing

experimental tricalcium silicateDRUG

prepared tricalcium silicate paste was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily. the patients were instructed to leave it for about 3minutes before rinsing

Eligibility

Sex: ALLMin age: 15 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with early enamel lesions (ICDAS score 1 and 2). * Patients with normal occlusion . * Patients must have a good oral hygiene * patients free from any systemic diseases and don't receive any medication Exclusion Criteria: * smoker patients * pregnant females * patients with bad oral hygiene * patients with enamel defects ( Amelogenesis Imperfecta, fluorosis, cracks or any developmental defects)

Locations (1)

Kareem Hamdi

Al Mansurah, Egypt

Outcomes

Primary Outcomes

Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents

The primary outcome was the change in laser fluorescence values that was detected by DIAGNODent Pen. The obtained values were interpreted according to the scale provided by the manufacture: * Value between (0-13) refers to sound enamel substrate * Value between (14-20) refers to early enamel caries

Time frame: 2-years after the first application of the remineralizing agents

Data from ClinicalTrials.gov

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