This study investigated the efficacy of adipose derived stem cell conditioned media (ADSC-CM) combined with minoxidil for hair regeneration therapy in male AGA.
This study was a double-blind, randomized clinical trial (RCT). Two concentrations of ADSC-CM were utilized: concentrated and non-concentrated ADSC-CM. The scalp was divided vertically in half; one side was injected with 2 ml of ADSC-CM, while the control side received 2 ml of NaCl 0,9%. After the injection, patients applied topical 5% minoxidil twice daily. Clinical improvements were assessed using photographic evaluation and trichoscan every two weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
37
Non-concentrated ADSC-CM is given during week 0, 2, 4, and 6 on the left side of the scalp. Minoxidil is applied twice using a spray, in the morning and at night.
Intervention is given during week 0, 2, 4, and 6 on the left side of the scalp. Minoxidil is applied twice using a spray, in the morning and at night.
Intervention is given during week 0, 2, 4, and 6 on the right side of the scalp. Minoxidil is applied twice using a spray, in the morning and at night.
Universitas Indonesia
Jakarta Pusat, Jakarta Special Capital Region, Indonesia
Hair count
Sum of hair
Time frame: Within 6 weeks
Hair density
count/cm2
Time frame: Within 6 weeks
Terminal rate
Percentage of terminal hairs
Time frame: Within 6 weeks
Vellus rate
Percentage of terminal hairs
Time frame: Within 6 weeks
Mean thickness
In centimeters
Time frame: Within 6 weeks
Total follicular units
Unit of hair follicles
Time frame: Within 6 weeks
7-point scale
In order to assess patient satisfaction of the research process and treatment outcome
Time frame: Within 6 weeks
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