Brain Substrates for Cardiovascular Stress Physiology

Baylor University40 enrolled

Overview

Transcranial infrared laser stimulation is a non-invasive neuromodulation technique. The study will examine the effect of transcranial infrared laser stimulation on cardiovascular and metabolic responses to stress.

Physiological responses to stress may be a potential pathway by which psychological stress relates to cardiovascular disease. Disproportionate (metabolically exaggerated) stressor-evoked cardiovascular reactions may accelerate atherosclerosis or influence risk of greater cardiovascular disease endpoints. The aim of this project is to use an experimental approach to examine if neuromodulation (transcranial infrared laser stimulation) alters stressor-evoked metabolic and cardiovascular responses.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Stress Reaction

Interventions

Low-level laser therapy (LLLT)OTHER

Sham Comparator: Participants will receive 8 counts of 60 seconds of the same laser to the right forehead, however the laser power will be turned off and will be 0 Watts. Transcranial infrared laser stimulation: Participants will receive 8 counts of 60 seconds of transcranial infrared laser stimulation to the right forehead. The wavelength will be 1064 nm and the laser power will be 3.4 Watts.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 18-30 years old Exclusion Criteria: History of a diagnosed chronic medical or neurological disorder Current pregnancy Current illness or infection (e.g., cold, flu) Any condition that would prohibit them from engaging in physical exercise

Locations (1)

Annie T. Ginty

Waco, Texas, United States

RECRUITING

Outcomes

Primary Outcomes

Oxygen consumption in response to acute psychological stress

This measurement takes into account oxygen consumption at baseline and during the stress task.

Time frame: Immediately following intervention (up to 60 minutes)

Heart rate in response to acute psychological stress

This measurement takes into account heart rate at baseline and during the stress task.

Time frame: Immediately following intervention (up to 60 minutes)

Additional heart rate in response to acute psychological stress

This measurement takes into account additional heart rate at baseline and during stress.

Time frame: Immediately following intervention (up to 60 minutes)

Secondary Outcomes

Perceived stress

Ratings of perceived stressfulness (1 = not at all stressful, 7 = very stressful) of the acute psychological stress task

Time frame: Immediately following intervention (up to 60 minutes)

Data from ClinicalTrials.gov

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