Post-ICU Follow-up Study in Covid-19 Patients

Sahlgrenska University Hospital793 enrolled

Overview

A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.

The spread of Covid19 in the population in Sweden from 2019 and onwards posed new and serious strain on our ICU capacity. The disease presented with initially influenza like symptoms and evolved into multiorgan failure. 5% of all patients with verified Covid 19 were in need of critical care and among them the in-hospital mortality rate was 20%. Patients will be followed up with after a minimum of three months after discharge from the ICU with regards to organ function. Examinations within the scope of the study are; * Comprehensive heart investigation including ultrasound * Arterial blood gas and lung function tests including computer tomography of the lungs. * Cognitive function with validated questioners * Standardized test of physical function * A panel of blood samples to assess organ function

Study Type

OBSERVATIONAL

Enrollment

793

Conditions

COVID-19 Pandemic Intensive Care Unit Syndrome Delirium

Interventions

Follow upOTHER

Comprehensive follow up in dedicated follow up unit

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients treated at the Intensive Care Unit at Mölndals hospital from 2020 to 2022 for Covid19 * More than 3 months passed since ICU discharge * Over 18 years of age at time of inclusion * Swedish resident with Swedish unique personal identification number. * Informed consent Exclusion Criteria: * Under 18 years of age at time of inclusion * Not a Swedish resident * Unwillingness to participate

Locations (1)

Sahlgrenska University Hospital

Mölndal, Västra Götaland County, Sweden

Outcomes

Primary Outcomes

Lung Function oxygen saturation

Respiratory function following Covid19, saturation in SaO2%

Time frame: One year

Lung Function, end tidal Co2 in kPa

Respiratory function following Covid19, end tidal carbon dioxide in kPa,

Time frame: One year

Lung Function, complete arterial and venous blood gas in kPa

Respiratory function with arterial and venous blood gas pO2 and pCO2 in kPa

Time frame: One year

Lung Function spirometry

Respiratory function with spirometry in Volumes in ml related to BMI

Time frame: One year

Lung parenchym status

Ct scan of the lungs, assessed by radiology specialist, assessed for fibrosis, bronchiectasia and residual ground glass abnormalities

Time frame: One year

ECG

5 lead ECG for the detection av arrythmia

Time frame: One year

Cardiac ultrasound

Cardiac ultrasound including ejection fractions (EF%)

Time frame: One year

Cardiac biomarkers Troponin in ng/L

Cardiac function Blood sampling

Time frame: One year

Cardiac biomarkers NTproBNPin ng/L

Cardiac function Blood sampling

Time frame: One year

Data from ClinicalTrials.gov

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Secondary Outcomes

Return to work

Are the subjects working or at the disposal of the labour market

Time frame: One year

Return to own home

Are the subjects living in their original housing or equivalent?

Time frame: one year

New need for nursing assistance at home?

Are the subjects in need of in home nursing care

Time frame: one year

Frailty

assessed accordingly to Clinical frailty scale

Time frame: One year

Mental fatigue

self-assessment questionnaire Mental fatigue scale

Time frame: One Year